Novel pyrrolidine derivatives as metap-2 inhibitors

Details Novel pyrrolidine derivatives as metap-2 inhibitors Novel pyrrolidine derivatives as metap-2 inhibitors

C - Chemistry, Metallurgy

07

D

C07D 473/34 (2006.01) A61K 31/519 (2006.01) A61K 31/52 (2006.01) A61P 35/00 (2006.01) C07D 471/04 (2006.01) C07D 487/04 (2006.01) C07D 519/00 (2006.01)

Patent

CA 2727282

The invention relates to compounds of formula (I), wherein R, X, Y, Z, R3 and R4 are defined as in claim 1. The compounds according to the invention are methionine aminopeptidase inhibitors and can be used in the treatment of tumors.

La présente invention concerne des composés de formule (I) dans laquelle R, X, Y, Z, R3 et R4 ont les significations énoncées dans la revendication 1, lesquels composés sont des inhibiteurs de la méthionine aminopeptidase et peuvent être utilisés pour traiter des tumeurs.

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