C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/54 (2006.01) C07K 16/40 (2006.01) C12N 9/12 (2006.01) C12N 9/16 (2006.01) C12Q 1/68 (2006.01) G01N 33/566 (2006.01)
Patent
CA 2173217
The present invention relates to a novel receptor-type protein tyrosine phosphatase protein or glycoprotein, term RPTP-sigma (also known as RPTPase-sigma); DNA encoding therefor, a restriction map of cDNA which is shown in the figure, antibodies specific for the protein or glycoprotein, methods for production and identification of the protein or glycoprotein, methods for detection of nucleic acid encoding the protein, and methods for screening compounds capable of binding to and either inhibiting or stimulating a RPTP-sigma phosphatase activity.
L'invention porte: sur une nouvelle protéine ou glycoprotéine thyrosine phosphatase à fonction récepteur dite RPTP - sigma ou RPTPase - sigma; sur l'ADN codant pour elle; sur une carte de restriction d'ADNc (fig 1); sur des anticorps spécifiques desdites protéines et glycoprotéines; des méthodes d'obtention et d'identification de la protéine; sur des méthodes de détection de l'acide nucléique codant pour lesdites protéines; et sur des méthodes de criblage de composés capables de se fixer aux RPTP- sigma et d'en inhiber ou stimuler l'activité phosphatase.
Schlessinger Joseph
Yan Hai
New York University
Osler Hoskin & Harcourt Llp
LandOfFree
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