Novel sulfonamide-substituted pyrazolopyridine derivatives

Details Novel sulfonamide-substituted pyrazolopyridine derivatives Novel sulfonamide-substituted pyrazolopyridine derivatives

C - Chemistry, Metallurgy

07

D

C07D 471/04 (2006.01) A61K 31/437 (2006.01) A61P 9/00 (2006.01) A61P 15/00 (2006.01) C07D 221/00 (2006.01) C07D 231/00 (2006.01)

Patent

CA 2429313

The invention relates to novel pyrazolopyridine derivatives of formula (I) wherein R1 represents H, Cl or NH2, and R2 and R3 form, together with the heteroatoms to which they are bonded, a five to six-membered heterocycle which can be saturated or partially unsaturated, can optionally contain at least one other heteroatom from the group N, O, S and can be optionally substituted. The invention also relates to salts, isomers and hydrates of said derivatives, in the form of stimulators of soluble guanylate cyclase and as agents for treating cardiovascular diseases, hypertonia, thrombo-embolic diseases and ischaemia, sexual dysfunction, inflammations, and diseases of the central nervous system.

L'invention concerne de nouveaux dérivés de pyrazolopyridine de formule (I), dans laquelle R?1¿ représente H, Cl ou NH¿2? et R?2¿ et R?3¿ représentent, avec les hétéroatomes auxquels ils sont reliés, un hétérocycle qui a cinq à sept chaînons, qui peut être saturé ou partiellement insaturé, qui peut éventuellement contenir un ou plusieurs autres hétéroatomes du groupe N, O, S et qui peut éventuellement être substitué, ainsi que des sels, des isomères et des hydrates de ces dérivés. Ces composés stimulent la guanylate cyclase soluble et sont utilisés comme médicaments pour traiter les maladies cardio-vasculaires, l'hypertonie, les maladies thromboemboliques et les ischémies, la dysfonction sexuelle, les inflammations ainsi que les maladies du système nerveux central.

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