A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/715 (2006.01) A61K 31/736 (2006.01)
Patent
CA 2327884
The present invention provides methods and means to influence neutrophil migration which occurs in a number of serious illnesses, such as acute trauma and inflammatory diseases. In bacterial meningitis for instance a high influx of neutrophils in the brain leads to an unfavourable prognosis. Typically IL-8 is involved in chemoattracts of neutrophils. According to the present invention glucoronoxylmannan or a functional equivalent thereof is used to interfere with neutrophil migration. This constitutes a first medical use of this group of substances.
L'invention concerne des procédés et des moyens servant à exercer une influence sur la migration des neutrophiles qui a lieu dans certaines maladies graves, telles que des traumatismes aigus ou des maladies inflammatoires. En ce qui concerne la méningite bactérienne, par exemple, une arrivée importante de neutrophiles dans le cerveau conduit à un pronostic défavorable. Il-8 est notamment impliqué dans le chimiotactisme des neutrophiles. Selon l'invention, on met en application glucuronoxylmannan ou un de ses équivalents fonctionnels afin que ces derniers jouent un rôle dans la migration des neutrophiles. Ceci constitue une première utilisation médicale de ce groupe de substances.
Academisch Ziekenhuis Utrecht
Borden Ladner Gervais Llp
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