Novel thiazolidin-4-one derivatives

Details Novel thiazolidin-4-one derivatives Novel thiazolidin-4-one derivatives

C - Chemistry, Metallurgy

07

D

C07D 417/00 (2006.01) A61K 31/425 (2006.01) A61K 31/44 (2006.01) A61K 31/495 (2006.01) A61K 31/535 (2006.01) C07D 277/14 (2006.01) C07D 277/34 (2006.01) C07D 417/04 (2006.01) C07D 417/06 (2006.01) C07D 417/14 (2006.01) C07D 473/00 (2006.01) C07D 473/08 (2006.01)

Patent

CA 2184174

The present invention relates to novel thiazolidin-4-one derivatives having formula (I), which inhibit platelet-activating factor and/or 5-lipoxygenase for the prevention or treatment of inflammatory and allergic disorders mediated by platelet-activating factor and/or leukotrienes, and to pharmaceutical compositions containing these compounds, and to the use thereof to inhibit PAF and/or leukotriene. A process for preparing these compounds is also included in the present invention, wherein n, T, Q, R1, R2, R3, R4, R5, R6, R7 and R8 are respectively as defined in the description.

L'invention concerne des nouveaux dérivés de thiazolidin-4-one de la formule (I), qui ont pour effet d'inhiber le facteur d'activation des plaquettes sanguines et/ou la 5-lipoxygénase dans le traitement prophylactique ou clinique des pathologies inflammatoires et allergiques induites par le facteur d'activation des plaquettes sanguines et/des leucotriènes. L'invention concerne également des compositions pharmaceutiques à base de ces composés ainsi que leur utilisation pour inhiber le facteur d'activation des plaquettes sanguines et/ou les leucotriènes. Elle comprend en outre un procédé destiné à la préparation de ces composés, qui est représenté par la formule (I) dans laquelle n, T, Q, R?1¿, R?2¿, R?3¿, R?4¿, R?5¿, R?6¿, R?7¿ et R?8¿ ont chacun la notation mentionnée dans la description.

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