Nuclear receptor ligands and ligand binding domains

Details Nuclear receptor ligands and ligand binding domains Nuclear receptor ligands and ligand binding domains

A - Human Necessities

61

K

A61K 31/195 (2006.01) A61K 31/192 (2006.01) A61K 31/198 (2006.01) A61K 31/27 (2006.01) C07K 14/72 (2006.01)

Patent

CA 2314096

The present invention provides new methods, particularly computational methods, and compositions for the generation of nuclear receptor synthetic ligands based on the three dimensional structure of nuclear receptors, particularly the thyroid receptor (herein referred to as "TR"). Also provided are crystals, nuclear receptor synthetic ligands, and related methods.

La présente invention concerne de nouvelles méthodes, en particulier de nouvelles méthodes computationnelles, ainsi que des compositions permettant de générer des ligands synthétiques de récepteurs nucléaires sur la base de la structure tridimensionnelle de récepteurs nucléaires, notamment le récepteur thyroïdien (ci-après désigné TR). L'invention concerne également des cristaux, des ligands synthétiques de récepteurs nucléaires, et les méthodes y relatives.

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