Nucleic acid and corresponding protein entitled 161p2f10b...

Details Nucleic acid and corresponding protein entitled 161p2f10b... Nucleic acid and corresponding protein entitled 161p2f10b...

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A01K 67/027 (2006.01) A61K 31/7088 (2006.01) A61K 35/14 (2006.01) A61K 38/17 (2006.01) A61K 39/395 (2006.01) A61K 47/48 (2006.01) A61K 48/00 (2006.01) A61K 49/16 (2006.01) C07K 14/47 (2006.01) C07K 16/30 (2006.01) C12Q 1/68 (2006.01) G01N 33/574 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2462653

A novel gene 0161P2F10B (also designated 161P2F10B) and its encoded protein, and variants thereof, are described wherein 161P2F10B exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, 161P2F10B provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The 161P2F10B gene of fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with 161P2F10B can be used in active or passive immunization.

L'invention concerne un nouveau gène 0161P2F10B (également appelé 161P2F10B) et sa protéine codée, ainsi que des variants de ceux-ci. 161P2F10B présente une expression spécifique de tissu dans un tissu adulte normal et il est exprimé de façon aberrante dans les cancers répertoriés dans le tableau I. De ce fait, 161P2F10B peut servir de cible diagnostique, pronostique, prophylactique et/ou thérapeutique pour le cancer. Le gène 161P2F10B ou un fragment de celui-ci, ou sa protéine codée, ou encore des variants de ceux-ci, ou un fragment de ceux-ci, peuvent être utilisés pour déclencher une réponse immunitaire humorale ou cellulaire ; des anticorps ou des lymphocytes réagissant avec 161P2F10B peuvent être utilisés en immunisation active ou passive.

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