Nucleic acid and corresponding protein entitled 238p1b2...

Details Nucleic acid and corresponding protein entitled 238p1b2... Nucleic acid and corresponding protein entitled 238p1b2...

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A01K 67/027 (2006.01) A61K 31/7088 (2006.01) A61K 35/14 (2006.01) A61K 38/08 (2006.01) A61K 38/17 (2006.01) A61K 38/46 (2006.01) A61K 39/395 (2006.01) A61K 47/48 (2006.01) A61P 35/00 (2006.01) C07K 14/47 (2006.01) C12N 5/12 (2006.01) C12Q 1/68 (2006.01) G01N 33/574 (2006.01)

Patent

CA 2479049

A novel gene (designated 238P1B) and its encoded protein, and variants thereof, are described wherein 238P1B2 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, 238PL1B2 provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The 238P1B2 gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with 238P1B2 can be used in active or passive immunization.

La présente invention concerne un nouveau gène (appelé 238P1B2) et sa protéine codée, ainsi que des variants de celle-ci. Le gène 238P1B2 présente une expression spécifique de tissu dans un tissu adulte normal et il est exprimé de manière aberrante dans les cancers répertoriés dans le Tableau I. Par conséquent, le gène 238PL1B2 permet d'obtenir une cible diagnostique, prognostique, prophylactique et/ou thérapeutique pour le cancer. Le gène 238P1B2 ou un fragment de celui-ci, ou sa protéine codée, ou des variants de celle-ci, ou un fragment de celle-ci, peuvent être utilisés pour induire une réponse immunitaire humorale ou cellulaire. Des anticorps ou des lymphocytes T réagissant avec le gène 238P1B2 peuvent être utilisés dans l'immunisation active ou passive.

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