Nucleic acid ligands to hepatocyte growth factor/scatter...

C - Chemistry – Metallurgy – 07 – H

Patent

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C07H 21/04 (2006.01) A61K 48/00 (2006.01) C07H 21/00 (2006.01) C07H 21/02 (2006.01) C12N 15/11 (2006.01) C12N 15/85 (2006.01) C12N 15/86 (2006.01) C12Q 1/68 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2381004

The invention provides nucleic acid ligands to hepatocyte growth factor/scatter factor (HGF) and its receptor c-met. The invention also provides nucleic acid ligands to integrins. The nucleic acid ligands of the instant invention are isolated using the SELEX method. SELEX is an acronym for Systematic Evolution of Ligands by EXponential enrichment. The nucleic acid ligands of the invention are useful as diagnostic and therapeutic agents.

L'invention concerne des ligands d'acide nucléique au facteur de croissance/facteur de dispersion des hépatocytes HGH-SF et son récepteur c.met. L'invention concerne également des ligands d'acide nucléique aux intégrines. Les ligands d'acide nucléique décrits dans la présente invention sont isolés à l'aide de la méthode SELEX. SELEX étant un acronyme utilisé pour <= évolution systématique de ligands par enrichissement exponentiel >=. Ces ligands sont utiles comme agents de diagnostic et comme agents thérapeutiques.

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