Nucleic acids and corresponding proteins entitled 109p1d4...

Details Nucleic acids and corresponding proteins entitled 109p1d4... Nucleic acids and corresponding proteins entitled 109p1d4...

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A01K 67/027 (2006.01) A61K 31/7088 (2006.01) A61K 31/713 (2006.01) A61K 35/14 (2006.01) A61K 38/08 (2006.01) A61K 38/17 (2006.01) A61K 38/46 (2006.01) A61K 39/395 (2006.01) A61K 48/00 (2006.01) A61P 35/00 (2006.01) C07K 7/06 (2006.01) C07K 14/47 (2006.01) C07K 14/82 (2006.01) C07K 16/18 (2006.01) C07K 16/32 (2006.01) C12N 15/11 (2006.01) C12Q 1/68 (2006.01) G01N 33/574 (2006.01)

Patent

CA 2522994

A novel gene 109P1D4 and its encoded protein, and variants thereof, are described wherein 109P1D4 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table i. Consequently, 109P1D4 provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The 109P1D4 gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with 109P1D4 can be used in active or passive immunization.

L'invention porte sur un nouveau gène 109P1D4 et sa protéine codée, et sur des variants de celui-ci. 109P1D4 présente une expression spécifique du tissu dans le tissu normal d'un adulte, et est exprimé de manière aberrante dans les cancers répertoriés dans le Tableau I. En conséquence, 109P1D4 offre une cible diagnostique, pronostique, prophylactique et/ou thérapeutique du cancer. Le gène 109P1D4 ou un fragment de celui-ci, ou sa protéine codée, ou des variants ou un fragment de celui-ci, peut être utilisé pour déclencher une réponse immune humorale ou cellulaire; des anticorps ou des lymphocytes T réagissant à 109P1D4 peuvent être utilisés dans l'immunisation active ou passive.

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