Nucleoside derivatives as inhibitors of rna-dependent rna...

Details Nucleoside derivatives as inhibitors of rna-dependent rna... Nucleoside derivatives as inhibitors of rna-dependent rna...

C - Chemistry, Metallurgy

07

H

C07H 19/14 (2006.01) A61K 31/70 (2006.01)

Patent

CA 2490666

The present invention provides nucleoside compounds and certain derivatives thereof which are inhibitors of RNA-dependent RNA viral polymerase. These compounds are inhibitors of RNA-dependent RNA viral replication and are useful for the treatment of RNA-dependent RNA viral infection. They are particularly useful as inhibitors of hepatitis C virus (HCV) NS5B polymerase, as inhibitors of HCV replication, and/or for the treatment of hepatitis C infection. The invention also describes pharmaceutical compositions containing such nucleoside compounds alone or in combination with other agents active against RNA-dependent RNA viral infection, in particular HCV infection. Also disclosed are methods of inhibiting RNA-dependent RNA polymerase, inhibiting RNA- dependent RNA viral replication, and/or treating RNA-dependent RNA viral infection with the nucleoside compounds of the present invention.

L'invention concerne des composés nucléosides et certains dérivés de ceux-ci, lesquels sont des inhibiteurs de l'ARN polymérase virale ARN-dépendante. Ces composés sont des inhibiteurs de la réplication virale de l'ARN ARN-dépendante, et ils sont utilisés pour le traitement d'une infection virale à ARN ARN-dépendante. Ils sont particulièrement utiles en tant qu'inhibiteurs de la polymérase NS5B du virus de l'hépatite C (VHC), en tant qu'inhibiteurs de la réplication du VHC, et/ou pour le traitement d'une infection à hépatite C. La présente invention concerne également des compositions pharmaceutiques contenant de tels composés nucléosides seuls ou en combinaison avec d'autres agents actifs contre une infection virale à ARN ARN-dépendante, en particulier, l'infection à VHC. En outre, l'invention concerne des procédés permettant d'inhiber une ARN polymérase ARN-dépendante, d'inhiber la réplication virale de l'ARN ARN-dépendante et/ou à traiter une infection virale à ARN ARN-dépendante avec les composés nucléosides décrit dans cette invention..

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