Nucleotide analogues comprising a reporter moiety and a...

C - Chemistry – Metallurgy – 07 – H

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C07H 19/10 (2006.01) C07H 19/20 (2006.01) C07H 21/00 (2006.01) C12Q 1/68 (2006.01)

Patent

CA 2408143

Nucleotides comprising a reporter moiety and a polymerase enzyme blocking moiety in which the reporter moiety does not also act as a polymerase enzyme blocking moiety are described. Also described are compounds of Formula (I): wherein W is a phosphate group, B is a base, Y is a linker comprising an enzyme-cleavable group, R2 is a reporter moiety, R3 is selected from H or OH, Z and Z' are selected from H, OH, or a group X-R1, wherein X is a linker comprising an enzyme-cleavable group and R1 is a polymerase enzyme blocking group, provided that at least one of Z and Z' is X- R1.

L'invention porte: sur des nucléotides comportant un fragment reporter et un fragment de blocage d'une polymérase dans lesquels le fragment reporter n'agit pas seulement comme fragment de blocage d'une polymérase; et sur des composés de formule (I) dans laquelle: W est un groupe phosphate; B est une base; Y est un liant comprenant un groupe clivable par une enzyme; R?2¿ est un fragment reporter; R?3¿ est choisi parmi H ou OH; Z et Z' sont choisis parmi H, OH, ou un groupe X-R?1¿, dans lequel X est un liant comprenant un groupe clivable par une enzyme; et R?1¿ est un groupe de blocage de la polymérase sous réserve que l'un de Z et Z' soit X- R?1¿.

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