C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/57 (2006.01) A01K 67/027 (2006.01) A61K 31/7088 (2006.01) A61K 38/17 (2006.01) A61K 39/395 (2006.01) A61K 48/00 (2006.01) C07H 21/00 (2006.01) C07K 14/47 (2006.01) C07K 16/40 (2006.01) C12N 9/48 (2006.01) C12N 9/64 (2006.01) C12N 15/12 (2006.01) C12N 15/85 (2006.01) C12Q 1/68 (2006.01) C30B 29/58 (2006.01) G01N 33/53 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2462209
This invention relates to ADAM and Interactor genes which are associated with various diseases, including asthma. The invention also relates to the nucleotide sequences of these genes, isolated nucleic acids comprising these nucleotide sequences, and isolated polypeptides or peptides encoded thereby. The invention further relates to vectors and host cells comprising the disclosed nucleotide sequences, or fragments thereof, as well as antibodies that bind to the encoded polypeptides or peptides. Also related are ligands that modulate the activity of the disclosed genes or gene products. In addition, the invention relates to methods and compositions employing the disclosed nucleic acids, polypeptides or peptides, antibodies, or ligands for use in diagnostics and therapeutics for asthma and other diseases.
L'invention concerne des gènes ADAM et Interactor associés à des maladies variées, notamment l'asthme. L'invention concerne également les séquences nucléotidiques de ces gènes, des acides nucléiques isolés comprenant ces séquences nucléotidiques, et des polypeptides isolés ou des peptides codant ceux-ci. L'invention concerne encore des vecteurs et des cellules hôtes comprenant lesdites séquences nucléotidiques, ou des fragments de celles-ci, ainsi que des anticorps se liant aux polypeptides ou aux peptides codés. En outre, l'invention concerne des ligands modulant l'activité des gènes ou des produits géniques susmentionnés. En outre, l'invention concerne des procédés et des compositions faisant appel aux acides nucléiques, aux polypeptides ou aux peptides, ou aux anticorps, ou aux ligands à utiliser dans un diagnostic ou dans une thérapie pour l'asthme et pour d'autres maladies.
Allen Kristina
Del Mastro Richard G.
Dupuis Josee
Keith Tim
Little Randall D.
Genome Therapeutics Corporation
Sim & Mcburney
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