C - Chemistry – Metallurgy – 07 – H
Patent
C - Chemistry, Metallurgy
07
H
C07H 17/00 (2006.01) A61K 31/70 (2006.01) C07H 17/08 (2006.01)
Patent
CA 2046956
The invention relates to O-methyl derivatives of azithromycin A of the formula (I) Image wherein Ia R1 = R2 = CO2CH2C6H5, R3 = CH3, R4 = R5 = H Ib R1 = R2 = CO2CH2C6H5, R3 = R4 = CH3, R5 = H Ic R1 = R2 = CO2CH2C6H5, R3 = R5 = H, R4 = CH3 Id R1 = R2 = CO2CH2C6H5, R3 = R4 = R5 = CH3 Ie R1 = R2 = R4 = R5 = H, R3 = CH3 If R1 = R2 = R5= H, R3 = R4 = CH3 Ig R1 = R2 = R3 = R5 = H, R4 = CH3 Ih R1 = R2,= H, R3 = R4 = R5 = CH3 li R1 = R4 = R5 = H, R2 = R3 = CH3 Ij R1 = R5 = H, R2 = R3 = R4 = CH3 Ik R1 = R3 = R5 = H, R2 = R4 = CH3 Il R1 = H, R2 = R3 = R4 = R5 = CH3 to their pharmaceutically acceptable addition salts with inorganic or organic acids, to a process for their preparation and to their use in the obtaining of antibacterialpharmaceutical preparations.
L'invention concerne des dérivés O-méthyliques de l'azithromycine A de formule (I) Image , dans laquelle Ia R1 = R2 = CO2CH2C6H5, R3 = CH3, R4 = R5 = H; Ib R1 = R2 CO2CH2C6H5, R3 = R4 = CH3, R5 = H; Ic R1 = R2 =CO2CH2C6H5, R3 = R5 = H, R4 = CH3; Id R1 = R2 = CO2CH2C6H5, R3 = R4 = R5 = CH3; Ie R1 = R2 = R4 = R5 = H, R3 = CH3; If R1 = R2 = R5 = H, R3 = R4 = CH3; Ig R1 = R2 = R3 = R5 = H, R4 = CH3; Ih R1 = R2 = H, R3 = R4 = R5 = CH3; Ii R1 = R4 = R5 = H, R2 = R3 = CH3; Ij R1 = R5 = H, R2 = R3 = R4 = CH3; Ik R1 = R3 = R5 = H, R2 = R4 = CH3; Il R1 = H, R2 = R3 = R4 = R5 = CH3, leurs sels d'addition d'utilisation pharmaceutique avec des acides organiques ou inorganiques, un procédé pour les préparer et leur utilisation dans la préparation de produits pharmaceutiques antibactériens.
Djokic Slobodan
Kobrehel Gabrijela
Lazarevski Gorjana
Borden Ladner Gervais Llp
Djokic Slobodan
Kobrehel Gabrijela
Lazarevski Gorjana
Prehrambena I. Kozmeticka Industrija S.p.o. Pliva Farmaceutska Kemijska
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