O-sulfated .beta.-lactam hydroxamic acids

C - Chemistry – Metallurgy – 07 – D

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C07D 487/10 (2006.01) C07D 205/12 (2006.01) C07D 417/12 (2006.01) C07D 491/10 (2006.01) C07D 491/107 (2006.01) C07D 495/10 (2006.01)

Patent

CA 1273938

ABSTRACT Antibacterial activity is exhibited by compounds having the formula Image and pharmaceutically acceptable salts thereof, wherein R1 is hydrogen or an acyl group as used in the penicillin or cephalosporin art; n and m are each independently 1, 2 or 3 and X is a saturated carbon to carbon bond; n and m are each independently 1, 2, 3 or 4, the sum of n+m?5 and X is -O-, -S-, Image ; n and m are each independently 1, 2 or 3, the sum of n+m?4 and X is Image or Image ; n and m are each independently 1 or 2, the sum of n+m?3 and X is Image ; or n and m are each 1 and X is -S-CH2-S-, Image , Image or Image ; R2 is alkyl, aryl, hydroxy, alkoxy, alkan- oyloxy, carbamoyloxy, alkanoylamino or ureido; R3 is hydrogen, alkyl, aryl, alkanoyl, or carbamoyl; and R4 is hydrogen, alkyl or aryl.

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