C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 295/22 (2006.01) C07C 291/08 (2006.01) C07D 207/16 (2006.01) C07D 213/64 (2006.01) C07D 239/34 (2006.01) C07D 295/28 (2006.01) C07H 15/00 (2006.01)
Patent
CA 2266908
Diazeniumdiolates, wherein the N1 position is substituted by an inorganic or organic moiety and the O2-oxygen is bound to a substituted or unsubstituted aromatic group, are provided. Also provided are O2-glycosylated 1-substituted diazen-1-ium-1,2-diolates (O2-glycosylated diazeniumdiolates) and O2- substituted 1-[(2-carboxylato)pyrrolidin-1-yl]diazen-1-ium-1,2-diolates (1-[(2- carboxylato)pyrrolidin-1-yl]diazeniumdiolates). The O2-aryl diazeniumdiolates are stable with respect to the hydrolytic generation of nitric oxide in neutral to acidic solutions and generate nitric oxide in basic or nucleophilic environments or microenvironments. Also provided are compositions, including pharmaceutical compositions, comprising such compounds and methods of using such compounds.
Cette invention se rapporte à des diazéniumdiolates, dans lesquels la position N?1¿ est substituée par une fraction inorganique ou organique et l'oxygène O?2¿ est lié à un groupe aromatique substitué ou insubstitué. Cette invention présente également des diazén-1-ium-1,2-diolates 1-substitutés O?2¿-glycosylés (diazéniumdiolates O?2¿-glycosylés) et des 1-[(2-carboxylato)pyrrolidin-1-yl]diazén-1-ium-1,2-diolates O?2¿-substitués (1-[(2-carboxylato)pyrrolidin-1-yl]diazéniumdiolates). Les diazéniumdiolates O?2¿-aryle sont stables par rapport à la production hydrolytique d'oxyde nitrique dans des solutions neutres à acides et génèrent de l'oxyde nitrique dans des environnements ou des microenvironnements basiques ou nucléophiles. Cette invention se rapporte également à des compositions, y compris des compositions pharmaceutiques, comprenant ces composés, ainsi qu'à des procédés d'utilisation de ces composés.
Bogdan Christian
Ji Xinhua
Keefer Larry K.
Rice William G.
Saavedra Joseph E.
Department Of Health And Human Services The Government Of The United States Of America Represented By Th
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
LandOfFree
O2-arylated or o2-glycosylated 1-substituted... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with O2-arylated or o2-glycosylated 1-substituted..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and O2-arylated or o2-glycosylated 1-substituted... will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1643212