Ob protein receptor and related compositions and methods

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/19 (2006.01) A61K 38/19 (2006.01) A61P 3/04 (2006.01) C07K 14/715 (2006.01)

Patent

CA 2240394

The present invention relates to a novel class of protein receptors, herein denominated "OB protein receptors" or "OB receptors", which are thought to selectively bind OB protein. As such, the novel OB protein receptor family is provided, as well as novel members of such family. Also provided are nucleic acids, vectors and host cells containing such nucleic acids, related antisense nucleic acids, molecules which selectively bind to the OB protein receptor, and related compositions of matter, such as OB receptor protein/OB protein complexes and pharmaceutical compositions. In other aspects, the present inventon relates to methods of using the above compositions, such as therapeutic and/or diagnostic methods, and methods for preparing OB receptor ligands.

La présente invention concerne une nouvelle classe de récepteurs de protéine, ci-après les "récepteurs de protéine OB" ou "récepteurs OB", dont on suppose qu'ils se lient sélectivement à la protéine OB. En tant que telle, l'invention concerne non seulement la nouvelle famille de récepteurs de la protéine OB mais aussi de nouveaux membres d'une telle famille. L'invention concerne également des acides nucléiques, des vecteurs et des cellules hôte contenant de tels acides nucléiques, les acides nucléiques antisens associés, les molécules qui se lient sélectivement au récepteur de la protéine OB, et aux compositions associées, telles que les complexes protéine récepteur OB / protéine OB et les compositions pharmaceutiques. Sous d'autres aspects, l'invention concerne des procédés d'utilisation des compositions susmentionnées, et notamment des thérapies et/ou des procédés de diagnostic ainsi que des procédés de préparation de ligands de récepteurs de la protéine OB.

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