C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/00 (2006.01) C07K 14/705 (2006.01) C12N 15/11 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2377937
The present invention relates to antisense oligonucleotides for metabotropic glutamate receptor type 1 (mGluR1). There is provided oligonucleotides that hybridize to a mRNA encoding mGluR1 or a splice variant thereof. There is also provided a method for treating a patient having a disorder related to an elevated glutamate level, such as chronic pain, or to enhance an opioid effect or to reduce opioid dependence and/or tolerance, which comprises the administration of such an oligonucleotide. Specific pain treatment is thereby obtained.
La présente invention concerne des oligonucléotides antisens de récepteur type 1 de glutamate métabotropique (mGluR¿1?). Cette invention a également trait à des oligonucléotides qui s'hybrident à un ARNm codant mGluR¿1? ou un variant d'épissure correspondant, à une méthode de traitement d'un patient souffrant d'un trouble lié à un taux de glutamate élevé, tel qu'une douleur chronique, ou d'amélioration d'un effet opioïde ou de diminution d'une dépendance et/ou tolérance opioïde consistant à administrer un tel oligonucléotide. On obtient ainsi un traitement spécifique de la douleur.
Coderre Terence J.
Cohen S. Robin
Fundytus Marian E.
Henry James L.
Vainio Anneli
Mbm Intellectual Property Law Llp
University Mcgill
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