Oligonucleotide-containing microspheres, their use for the...

Details Oligonucleotide-containing microspheres, their use for the... Oligonucleotide-containing microspheres, their use for the...

A - Human Necessities

61

K

A61K 9/16 (2006.01) A61K 38/00 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2566199

This application refers to microspheres comprising oligonucleotides for treatment of type 1 diabetes, said oligonucleotides comprise between about 30 weight percent and about 100 weight percent of the microspheres, based on the total weight of the microspheres, said microspheres having an average particle size of not greater than about 50 microns. The oligonucleotides are targeted to bind to primary transcripts selected from the group consisting of CD40, CD80 and CD86 primary transcripts, and combinations thereof.

Selon cette invention, des oligonucléotides antisens sont administrés sous forme de microsphères afin d'induire la tolérance de cellules dendritiques, plus spécifiquement dans le modèle de souris non obèse diabétique (NOD). Ces microsphères comprennent des oligonucléotides antisens (AS). L'invention concerne également un procédé consistant à mettre en oeuvre une approche antisens pour empêcher un état de diabète insulino-dépendant dans des souris NOD in vivo et in situ. Les oligonucléotides sont ciblés pour se lier à des transcrits primaires CD40, CD80, CD86 et aux combinaisons de ceux-ci.

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