Oligonucleotide derivatives and production thereof

Details Oligonucleotide derivatives and production thereof Oligonucleotide derivatives and production thereof

C - Chemistry, Metallurgy

07

H

195/1.12

C07H 21/00 (2006.01)

Patent

CA 1202254

ABSTRACT OF THE DISCLOSURE OLIGONUCLEOTIDE DERIVATIVES AND PRODUCTION THEREOF An oligonucleotide derivative having an amino group protected with an eliminatable group bonded through a phosphate group and a spacer with an appro- priate length to the 5'-end of an oligonucleotide protected suitably at the 3'-hydroxyl group and the base moiety of the nucleotide, and an immobilized oli- gonucleotide derivative having a Sepharose carrier bonded to the amino group in place of said protective group are disclosed. Methods for production of these derivatives are also disclosed.

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