C - Chemistry – Metallurgy – 07 – H
Patent
C - Chemistry, Metallurgy
07
H
C07H 21/02 (2006.01)
Patent
CA 2671873
This invention pertains to methods for oligonucleotide synthesis, specifically the synthesis of oligonucleotides that contain a high content of guanine monomers. In more detail, the invention relates to a method for coupling a nucleoside phosphoramidite during the synthesis of an oligonucleotide to a universal support, to a first nucleoside, or to an extending oligonucleotide. The invention further relates to oligonucleotides obtainable by the methods of the invention.
La présente invention concerne des procédés de synthèse d'oligonucléotide, plus spécifiquement la synthèse d'oligonucléotides qui contiennent une teneur élevée en monomères de guanine. De manière plus détaillée, l'invention concerne un procédé de couplage d'un phosphoramidite de nucléoside au cours de la synthèse d'un oligonucléotide à un support universel, à un premier nucléoside ou à un oligonucléotide d'extension. L'invention concerne en outre des oligonucléotides pouvant être obtenus au moyen des procédés de l'invention.
Cytos Biotechnology Ag
Integrated Dna Technologies Inc.
Smart & Biggar
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