Ophthalmic compound with extended dwell time on the eye

Details Ophthalmic compound with extended dwell time on the eye Ophthalmic compound with extended dwell time on the eye

A - Human Necessities

61

K

A61K 47/18 (2006.01) A61K 9/00 (2006.01) A61K 9/06 (2006.01) A61K 9/08 (2006.01) A61K 31/07 (2006.01)

Patent

CA 2251982

An ophthalmic compound with an extended dwell time on the eye, especially in the form of a drip gel, a salve or the like, containing a fluid base of increased viscosity and a preserving agent and possibly one or more active agents and common additives, like isotoning agents, substances for adjusting the pH, etc. According to the invention, the preserving agent consists essentially of a benzyl lauryl dimethyl ammonium salt. The invention also relates to the use of a benzyl lauryl dimethyl ammonium salt as a preserving agent in the production of ophthalmic compounds intended for repeated use over long periods and/or formulated for extended dwell time on the eye after each application, by means of which irritations of and/or tissue damage to the eye are prevented.

L'invention concerne une composition ophtalmique à temps de séjour prolongé au niveau de l'oeil, se présentant notamment sous forme de gel coulant facilement, de pommade ou similaire, qui contient un excipient coulant à viscosité élevée et un agent conservateur, ainsi qu'éventuellement un ou plusieurs principes actifs et des additifs traditionnels, tels que des agents d'isotonisation, des substances permettant d'ajuster le pH, etc. Selon l'invention, l'agent conservateur se compose essentiellement d'un sel de benzyllauryldiméthylammonium. L'invention concerne en outre l'utilisation d'un sel de benzyllauryldiméthylammonium comme agent conservateur pour préparer des compositions ophtalmiques convenant à une utilisation répétée sur de longues périodes et/ou dont la formulation est adaptée à un temps de séjour prolongé au niveau de l'oeil après chaque application, ce qui permet d'éviter des phénomènes d'irritation et/ou des altérations du tissu oculaire.

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