C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 417/06 (2006.01) A61K 31/495 (2006.01) A61K 38/05 (2006.01) C07D 211/34 (2006.01) C07D 211/70 (2006.01) C07D 213/38 (2006.01) C07D 213/75 (2006.01) C07D 213/82 (2006.01) C07D 241/04 (2006.01) C07D 277/28 (2006.01) C07D 295/03 (2006.01) C07D 295/096 (2006.01) C07D 295/135 (2006.01) C07D 295/155 (2006.01) C07D 295/192 (2006.01) C07D 333/20 (2006.01) C07D 333/28 (2006.01) C07D 333/38 (2006.01) C07D 401/06 (2006.01) C07D 403/06 (2006.01) C07D 409/06 (2006.01) C07K 5/06 (2006.01) C07K 5/065 (2006.01) C12P 4
Patent
CA 2129046
Diarylmethyl piperazine/piperidine compounds of formula (1) as shown above wherein the substituents are as defined in the description having utility as exogenous receptor combinant species for binding with receptors such as delta, mu, sigma, and/ or kappa receptors. Compounds of the invention may be employed as conjugates in agonist/antagonist pairs for transductional monitoring and assays of neurotransmitter function, and also variously exhibit therapeutic utility, including mediating analgesia, and possessing utility for the treatment of diarrhea, urinary incontinence, mental illness, drug and alcohol addiction/overdose, lung edema, depression, asthma, emphysema, and apnea, cognitive disorders, and gastrointestinal disorders.
Boswell Grady Evan
Bubacz Dulce Garrido
Chang Kwen-Jen
Collins Mark Allan
Davis Ann Otstot
Mount Cook Biosciences Inc.
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
The Wellcome Foundation Limited
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