Optical sensor for determining the concentration of an analyte

Details Optical sensor for determining the concentration of an analyte Optical sensor for determining the concentration of an analyte

A - Human Necessities

61

B

A61B 5/00 (2006.01) G01N 21/49 (2006.01)

Patent

CA 2704789

A method and apparatus for non-invasively determining a concentration of glucose in a subject using optical excitation and detection is provided. The method includes emitting an exciter beam to irradiate a portion of tissue of the subject, causing physical and chemical changes in the surface, and causing an initial back scattering of light. The method further includes periodically emitting a probe beam which irradiates the portion of tissue and causes periodic back scatterings of light. The initial and periodic back scatterings are detected and converted into electrical signals of at least the amplitude, frequency or decay time of the physical and chemical changes, the back scatterings being modulated by the physical and chemical changes. By differentiating over time at least one of the amplitude, frequency or decay time of the physical and chemical changes, the concentration of glucose may be determined.

L'invention propose un procédé et un appareil pour déterminer de manière non invasive la concentration de glucose chez un sujet à l'aide d'une excitation optique et d'une détection. Le procédé comprend l'émission d'un faisceau d'excitation pour irradier une partie tissulaire du sujet, provoquant des changements physiques et chimiques dans la surface et provoquant une rétrodiffusion initiale de lumière. Le procédé comprend en outre une émission périodique d'un faisceau de sonde qui irradie la partie de tissu et qui provoque des rétrodiffusions périodiques de lumière. Les rétrodiffusions initiales et périodiques sont détectées et converties en signaux électriques d'au moins l'amplitude, la fréquence ou le temps de descente des changements physiques et chimiques, les rétrodiffusions étant modulées par les changements physiques et chimiques. Par la différenciation temporelle de l'amplitude et/ou de la fréquence et/ou du temps de descente des changements physiques et chimiques, on peut déterminer la concentration de glucose.

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