Optically active thiazolidinone derivatives

Details Optically active thiazolidinone derivatives Optically active thiazolidinone derivatives

C - Chemistry, Metallurgy

07

D

C07D 277/14 (2006.01) A61K 31/42 (2006.01) A61K 31/425 (2006.01) A61K 31/435 (2006.01) A61K 31/495 (2006.01)

Patent

CA 2214386

An optically active thiazolidinone derivative having the general formula: (see formula I) [wherein R1 represents a hydrogen atom, a C1-C4 alkyl group, a phenyl group, a substituted phenyl group (said substituent represents C1-C4 alkyl, C1-C4 alkoxy or halogen) , a phenyl-C1-C2 alkyl group or a substituted phenyl-C1-C2 alkyl group (the substituent of said phenyl represents C1-C4 alkyl, C1-C4 alkoxy or halogen); R2 represents a C1-C6 alkyl group; and n represents 1 or 2]. The optically active thiazolidinone derivative of the present invention has excellent anti-angina pectoris action and is useful as a preventive agent or a therapeutic agent for angina pectoris.

L'invention concerne des dérivés de thiazolidinone optiquement actifs, de formule générale (I), où R<1> représente hydrogène, alkyle C1-C4, phényle (éventuellement substitué par alkyle C1-C4, alcoxy C1-C4 ou halogéno), ou phénylalkyle C1-C2 (éventuellement substitué par alkyle C1-C4, alcoxy C1-C4 ou halogéno); R<2> représente alkyle C1-C4, et n est égal à 1 ou 2. Ces composés présentent un excellent effet antiangineux, et peuvent donc être utilisés pour la prévention et le traitement des angines de poitrine. Ils présentent également un effet antiulcéreux et peuvent donc être utilisés pour la prévention et le traitement des affections ulcéreuses.

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