Optimized antibodies that target hm1.24

Details Optimized antibodies that target hm1.24 Optimized antibodies that target hm1.24

C - Chemistry, Metallurgy

07

K

C07K 16/30 (2006.01) A61K 39/395 (2006.01) A61P 35/00 (2006.01) A61P 37/00 (2006.01) C07K 16/28 (2006.01) C07K 14/705 (2006.01)

Patent

CA 2660795

The present disclosure describes antibodies that target HM1.24. In various aspects, the antibodies have specific CDR, variable, or full length sequences, have modifications with the parent antibody, or include at least one one modification relative to a parent antibodythat alters affinity to an Fc.gamma.R or alters effector function as compared to the parent antibody. Nucleic acids encoding the antibodies and methods of using the antibodies are also disclosed.

La présente invention concerne des anticorps ciblant l'antigène HM1.24. Selon divers aspects, les anticorps présentent une zone de détermination de complémentarité (CDR) spécifique, des séquences variables ou de pleine longueur, des modifications avec l'anticorps parent, ou comprennent au moins une modification par rapport à un anticorps parent modifiant l'affinité à un récepteur Fc.gamma.R ou modifiant une fonction effectrice par rapport à l'anticorps parent. Des acides nucléiques codant les anticorps et des procédés d'utilisation des anticorps sont également décrits.

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