Optimized cd40 antibodies and methods of using the same

Details Optimized cd40 antibodies and methods of using the same Optimized cd40 antibodies and methods of using the same

C - Chemistry, Metallurgy

07

K

C07K 16/28 (2006.01) A61K 39/395 (2006.01)

Patent

CA 2712989

The present invention describes humanized antibodies that target CD40, wherein the antibodies comprise at least one modification relative to a parent antibody, wherein the modification alters affinity to an Fc.gamma.R or alters effector function as compared to the parent antibody. Also disclosed are methods of using the antibodies of the invention.

La présente invention porte sur des anticorps humanisés qui ciblent CD40, les anticorps comprenant au moins une modification par rapport à un anticorps parent, la modification changeant l'affinité vis-à-vis d'un Fc?R ou changeant la fonction d'effecteur par comparaison avec l'anticorps parent. L'invention porte également sur des procédés d'utilisation des anticorps de l'invention.

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