C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/31 (2006.01) A61K 38/16 (2006.01) A61K 38/48 (2006.01) A61K 39/08 (2006.01) C07K 14/33 (2006.01) C12N 1/21 (2006.01) C12N 5/10 (2006.01) C12N 15/63 (2006.01) C12N 9/52 (2006.01)
Patent
CA 2575994
Nucleic acid molecules that comprise modified open reading frames providing increased expression of the encoded active BoNT/A in a heterologous cell, expression constructs and cells comprising such nucleic acid molecules and methods useful for expressing the encoding active BoNT/A from such nucleic acid molecules, expression constructs and cells.
La présente invention a trait à des molécules d'acide nucléique comportant des cassettes de lecture ouvertes assurant une expression accrue de la BoNT/A active codée dans une cellule hétérologue, à des constructions d'expression et à des cellules comprenant de telles molécules d'acide nucléique et à des procédés pour l'expression du codage de la BoNT/A active à partir de telles molécules d'acide nucléique, constructions d'expression et cellules.
Aoki Kei Roger
Fernandez-Salas Ester E.
Gilmore Marcella A.
Li Shengwen
Miller Ronald G.
Allergan Inc.
Gowling Lafleur Henderson Llp
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