Oral delivery of hydrophilic drugs to the brain

Details Oral delivery of hydrophilic drugs to the brain Oral delivery of hydrophilic drugs to the brain

A - Human Necessities

61

K

A61K 47/18 (2006.01) A61K 47/36 (2006.01) A61K 47/48 (2006.01)

Patent

CA 2754140

A composition comprising a lipophilic derivative of a hydrophilic drug and an amphiphile compound for use in therapy wherein the composition is orally administered to the human or animal body. The invention includes derivatives such as palmitoylated Leucine [5]-Enkephalin and is useful in the treatment of schizophrenia, obsesity, pain and sleep disorders, psychiatric diseases, neurodegenerative conditions, brain cancers and infective diseases.

La présente invention concerne une composition comprenant un dérivé lipophile d'un médicament hydrophile et un composé amphiphile destiné à être utilisé en thérapie, la composition étant administrée par voie orale au corps humain ou animal. L'invention concerne des dérivés tels que la leucine[5]-encéphaline palmitoylée et est utile dans le traitement de la schizophrénie, de l'obésité, de la douleur et des troubles du sommeil, de maladies psychiatriques, de troubles neurodégénératifs, de cancers du cerveau et de maladies infectieuses.

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