Oral formulations for picoplatin

Details Oral formulations for picoplatin Oral formulations for picoplatin

A - Human Necessities

61

K

A61K 33/24 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2693057

The invention provides formulations for the organoplatinum anticancer drug picoplatin. Self emulsifying compo-sitions, stabilized nanoparticulate compositions, solid dispersions, and nanoparticulate suspensions in oils are provided, along with methods for preparation of the formulations. The formulations can provide improved oral availability of picoplatin relative a to a simple solution of picoplatin such as in water or normal saline solution and can be used in combination therapy.

L'invention propose des formulations pour le médicament anticancéreux organoplatiné picoplatine. Des compositions auto-émulsifiantes, des compositions de nanoparticules stabilisées, des dispersions solides et des suspensions de nanoparticules dans des huiles sont proposées, ainsi que des procédés pour la préparation des formulations. Les formulations peuvent procurer une disponibilité orale améliorée du picoplatine par rapport à une simple solution de picoplatine, comme dans de l'eau ou dans une solution saline normale, et peuvent être utilisées dans une thérapie combinée.

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