C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 471/04 (2006.01) A61K 31/437 (2006.01) A61P 11/00 (2006.01) A61P 19/00 (2006.01)
Patent
CA 2703037
Compounds of formula I: in free or salt or solvate form, where R1, R2, R3 and R20 have the meanings as indicated in the specification, are useful tor treating diseases mediated by the ALK-5 and/or ALK-4 receptor. Pharmaceutical compositions that contain the compounds and processes for preparing the compounds are also described. These compounds are useful for the treatment of inflammatory or obstructive airways diseases such as pulmonary hypertension, pulmonary fibrosis, liver fibrosis, cancer, muscle diseases such as muscle atrophies and muscle dystrophies, and systemic skeletal disorders such as osteoporosis.
La présente invention concerne des composés de formule (I) : sous une forme libre ou de sel ou de solvate, dans laquelle R1, R2, R3 et R20 ont les significations indiquées dans la spécification, qui sont utiles pour traiter des maladies induites par le récepteur ALK-5 et/ou ALK-4. L'invention concerne également des compositions pharmaceutiques qui contiennent les composés et des procédés de préparation des composés.
Furminger Vikki
Hornsperger Benoit
Leblanc Catherine
Lewis Sarah
Lizos Dimitrios
Fetherstonhaugh & Co.
Novartis Ag
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