C - Chemistry – Metallurgy – 07 – F
Patent
C - Chemistry, Metallurgy
07
F
C07F 17/02 (2006.01) A61K 31/28 (2006.01)
Patent
CA 2676535
The present invention relates to novel organometallic compounds for use as a medicine, in particular in photodynamic therapy against various diseases, such as cancer or inflammatoryand/or immune disorders. The compounds comprise a central porphyrin or phtalocyanine backbone to which ligandlinkers coordinated to at least one transition metal are attached. Eta-5 or eta-6 arenes further bind to the transition metal. According to a preferred embodiment, the compound is a tetranuclear Ruthenium (+II) complex.
La présente invention porte sur de nouveaux composés organométalliques destinés à être utilisés comme médicament, en particulier dans une thérapie photodynamique contre diverses maladies, telles que le cancer ou des troubles inflammatoires et/ou immunitaires. Les composés comprennent un squelette central de porphyrine ou de phtalocyanine auquel sont attachés des éléments de liaison ligands coordonnés à au moins un métal de transition. Des êta-5 ou êta-6 arènes se lient en outre au métal de transition. Conformément à un mode de réalisation préféré, le composé est un complexe de Ruthénium (+II) tétranucléaire.
Ang Wee Han
Dyson Paul Joseph
Juillerat Lucienne
Padavattan Govindasvamy
Schmitt Frederic
Shapiro Cohen
Universite de Neuchatel
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