A - Human Necessities – 61 – F
Patent
A - Human Necessities
61
F
A61F 2/28 (2006.01) A61L 27/34 (2006.01) A61L 27/36 (2006.01) A61L 27/38 (2006.01)
Patent
CA 2339119
A method by which immune responses to cortical bone grafts and other substrates (e.g., cement, 1PN, etc.) can be minimized and at the same time graft osteoinductive potential can be improved, and improved graft substrate materials are disclosed. The method of the invention provides new types of bone grafts that incorporate into host bone more thoroughly and more rapidly, eliminating long-term complications, such as fracture, non-union, infection, and rejection. In the method of the invention, bone grafts or other substrates are modified to have an osteoinductive surface modification that the recipient's body will accept as its own tissue type and therefore will not reject or otherwise cause to fail. The osteoinductive surface modification comprises a biopolymer matrix coating that is seeded with periosteal cells that have been previously harvested either from the graft recipient or from an allogenic or xenogenic donor source.
L'invention concerne un procédé permettant de réduire au minimum des réactions immunitaires à des greffes de corticale et à d'autres substrats (p. ex. ciment, IPN, etc.), et en même temps d'améliorer le potentiel ostéo-inductif de la greffe ; et des matières de substrat de greffe améliorées. Le procédé de l'invention concerne de nouveaux types de greffes osseuses qui s'incorporent dans l'os hôte plus complètement et plus rapidement, ce qui permet de supprimer des complications à long terme telles que fracture, absence de consolidation, infection et rejet. Dans le procédé de l'invention, des greffes osseuses ou d'autres substrats sont modifiés de manière à présenter une modification de surface ostéo-inductive que le corps du receveur va accepter comme son propre type de tissu, et de ce fait ne va pas rejeter ou mettre en échec d'une autre manière. La modification de surface ostéo-inductive comporte un revêtement de matrice biopolymère ensemencé de cellules périostales qui ont été recueillies auparavant sur le receveur de greffe, ou qui proviennent d'une source de donneur homologue ou hétérologue.
Bondre Shrikar
Cattaneo Maurice V.
Gresser Joseph D.
Lewandrowski Kai-Uwe
Trantolo Debra J.
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Cambridge Scientific Inc.
Depuy Mitek Inc.
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