C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/30 (2006.01) A61K 31/337 (2006.01) A61K 39/395 (2006.01) A61K 47/42 (2006.01) A61K 47/48 (2006.01) A61P 35/00 (2006.01) C12N 5/18 (2006.01) C12P 21/08 (2006.01) G01N 33/567 (2006.01) G01N 33/574 (2006.01)
Patent
CA 2525840
The invention provides isolated anti-ovarian, pancreatic, lung or breast cancer antigen (Ovr115) antibodies that bind to Ovr115 on a mammalian cell in vivo. The invention also encompasses compositions comprising an anti-Ovr115 antibody and a carrier. These compositions can be provided in an article of manufacture or a kit. Another aspect of the invention is an isolated nucleic acid encoding an anti-Ovr115 antibody, as well as an expression vector comprising the isolated nucleic acid. Also provided are cells that produce the anti-Ovr115 antibodies. The invention encompasses a method of producing the anti-Ovr115 antibodies. Other aspects of the invention are a method of killing an Ovrl 15-expressing cancer cell, comprising contacting the cancer cell with an anti~-Ovr115 antibody and a method of alleviating or treating an Ovrl 15- expressing cancer in a mammal, comprising administering a therapeutically effective amount of the anti-Ovr115 antibody to the mammal.
L'invention concerne des anticorps (Ovr115) d'antigènes du cancer du sein et du poumon, pancréatique, anti-ovarien isolé qui se lient à Ovr115 sur une cellule mammifère in vivo. Cette invention concerne également des compositions contenant un anticorps anti-Ovr115 et un excipient. Ces compositions peuvent être utilisées dans un article de fabrication ou un nécessaire. Un autre aspect de cette invention réside dans un acide nucléique isolé codant un anticorps anti-Ovr115, ainsi qu'un vecteur d'expression comprenant cet acide nucléique isolé. L'invention concerne également des cellules qui produisent ces anticorps anti-Ovr115. L'invention concerne enfin un procédé de production d'anticorps anti-Ovr115. Parmi d'autres aspects de l'invention, on compte un procédé d'élimination d'une cellule cancéreuse exprimant Ovr115, qui consiste à mettre en contact la cellule cancéreuse avec un anticorps anti-Ovr115 et un procédé destiné à soulager ou à traiter un cancer exprimant l'Ovr115 chez un mammifère, consistant à administrer une quantité efficace sur le plan thérapeutique de l'anticorps anti-Ovr115 au mammifère.
Corral Laura
Keller Gilbert-Andre
Li Wenlu
Pilkington Glenn
Simon Iris
Borden Ladner Gervais Llp
Diadexus Inc.
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