Oxaindene derivatives and process for the preparation thereof

Details Oxaindene derivatives and process for the preparation thereof Oxaindene derivatives and process for the preparation thereof

C - Chemistry, Metallurgy

07

D

C07D 307/93 (2006.01) A61K 31/34 (2006.01) A61K 31/445 (2006.01) A61K 31/535 (2006.01) C07D 307/91 (2006.01)

Patent

CA 2180029

This invention relates to new oxaindene derivatives, a process for the preparation thereof and pharmaceutical compositions comprising the same. The compounds according to the invention are characterized by the general formula (I) (I) Image wherein R1 represents lower C1-4alkyl, lower C1-4 alkoxy or lower C3-6 cycloalkyl, R2 stands for hydrogen, lower C1-4 alkyl or lower C3-6 cycloalkyl, R3 stands for hydrogen, lower C1-4 alkyl, lower C1-4 alkoxy or benzyloxy, X denotes hydrogen, an aliphatic C1-4-acyl or benzoyl or naphthoyl group, optionally substituted by 1 or more nitro or C1-4-alkoxy group(s) or a group of the formula R5R6=N-R7, wherein R5, R6 and R7 each represent lower C1-4 alkylene, or R5 and R6 together with the nitrogen atom to which they are attached form a piperidyl or morpholinyl group, A and B together form an ethylene or a vinylene group, and n is 1,2 or 3, and have a strong 5-lipoxygenase (5-LO) enzyme inhibiting activity.

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