Oxygen-containing heterocyclic compounds

Details Oxygen-containing heterocyclic compounds Oxygen-containing heterocyclic compounds

C - Chemistry, Metallurgy

07

D

C07D 405/06 (2006.01) A61K 31/343 (2006.01) A61K 31/443 (2006.01) A61P 37/08 (2006.01) C07D 307/86 (2006.01) C07D 307/94 (2006.01) C07D 405/12 (2006.01) C07D 405/14 (2006.01)

Patent

CA 2195755

An oxygen-containing heterocyclic compound represented by following Formula (I): Image wherein R1 and R2 independently represent hydrogen, lower alkyl, cyano, -(CH2)n-E-CO-F (wherein E represents a bond, O, or NH; F represents OR6 or NR7R8; and n represents an integer of 0 to 4), or the like; R1 and R2 are combined to represent a saturated carbon ring together with a carbon atom adjacent thereto; or R2, and R11 or R13 described below are combined to form a single bond; R3 represents hydrogen, phenyl, or halogen; R4 represents hydroxy, lower alkoxy, or the like; A represents -C(R9)(R10)- or O; B represents O, NR11,-C (R12) (R13) -, or -C (R14 ) (R15) - C(R16)(R17)-; D represents (i) -C(R18)(R19)-X- (wherein X represents -C(R21)(R22)-, S, or NR23), (ii) -C(R19a)=Y- [Y represents -C(R24)-Z- (wherein Z represents CONH, CONHCH2, or a bond), or N], or (iii) a bond; and R5 represents aryl, an aromatic heterocyclic group, cycloalkyl, pyridine-N- oxide, cyano, or lower alkoxycarbonyl; or a pharmaceutically acceptable salt thereof.

Composés hétérocycliques contenant de l'oxygène, représentés par la formule générale (I), ou leurs sels pharmacologiquement acceptables, dans laquelle R<1> et R<2>, identiques ou différents, représentent chacun hydrogène, alkyle inférieur, cyano ou -(CH2)n-E-CO-F (où E représente une liaison, O ou NH; F représente OR<6> ou NR<7>R<8>; et n est un entier de 0 à 4), ou encore R<1> et R<2> ensemble peuvent avec l'atome de carbone adjacent former un noyau carbocyclique saturé, ou R<2> avec R<11> ou R<13>, décrits ci-dessous, peut former une liaison unique; R<3> représente hydrogène, phényle ou halogéno; R<4> représente hydroxy, alcoxy inférieur, etc.; A représente -C(R 9)(R<10>)- ou O; B représente O, NR<11>, -C(R<12>)(R<13>)- ou -C(R<14>)(R<15>)-C(R<16>)(R<17>)-; D représente (1) -C(R<18>)(R<19>)-X [où X représente -C(R<21>)(R<22>)-, S ou NR<23>], (2) -C(R<19a>)=Y- [où Y représente -C(R<24>)-Z-, {où Z représente CONH, CONHCH2 ou une liaison}, ou N] ou (3) une liaison; et R<5> représente aryle, hétéroaryle, cycloalkyle, pyridine-N-oxyde, cyano ou alcoxycarbonyle inférieur.

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