P-hydroxy phenone derivatives and the use thereof

Details P-hydroxy phenone derivatives and the use thereof P-hydroxy phenone derivatives and the use thereof

C - Chemistry, Metallurgy

07

C

167/179, 260/578

C07C 217/22 (2006.01) A61K 31/395 (2006.01) C07D 295/08 (2006.01) C07D 295/092 (2006.01)

Patent

CA 1325009

- 15 - Abstract of the Disclosure: p-Hydroxy phenone derivatives of the general formula I Image I, where R1, R2 and R3 are identical or different and are methyl, chlorine, bromine and hydrogen, but R1, R2 and R3 are not all H, R4 and R5 are identical or different and are H, C1-C4- alkyl, or OR6, but R4 and R5 are not both H, X is a -CH=CH-, -CH2CH2 or -CH2- bridge, Y is a straight-chain or branched, saturated or unsatur- ated C1-C4 bridge, and Z is NR6R7, where R6 and R7 are, independently of one another, hydrogen or C1-4-alkyl, or Z is a 5- or 6-mem- bered ring with a nitrogen atom in the 1 position and, where appropriate, additionally a second N atom or an O or S atom, the second N atom being substituted by R7, as well as the physiologically tolerated salts thereof, are used to prepare drugs antiarrhythmic of Vaughan- Williams class III.

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