P-selectin ligand proteins

Details P-selectin ligand proteins P-selectin ligand proteins

A - Human Necessities

61

K

A61K 47/48 (2006.01) A61K 38/16 (2006.01) A61P 9/10 (2006.01) A61P 29/00 (2006.01) A61P 37/06 (2006.01)

Patent

CA 2599944

A novel P-selection ligand glycoprotein is disclosed, comprising the amino acid sequence set forth in SEQ ID NO 2 or by the amino acid sequence set forth in SEQ ID NO 4. DNA sequences encoding the P-selectin ligand protein are also disclosed, along with vectors, host cells, and methods of making the P-selectin ligand protein. Pharmaceutical compositions containing the P-selectin ligand protein and methods of treating inflammatory disease states characterised by P-selectin- and E-selectin-mediated intercellular adhesion are also disclosed.

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