Pa28 modified transgenic mice

Details Pa28 modified transgenic mice Pa28 modified transgenic mice

A - Human Necessities

01

K

A01K 67/027 (2006.01) C07K 14/47 (2006.01) C12N 15/00 (2006.01)

Patent

CA 2382381

A transgenic mouse with alterations in a PA28.beta. gene is prepared by introduction of an altered PA28.beta. gene into a host mouse. The resulting transgenic animals do not produce functional PA28 molecules. Cells and cell lines derived from these animals also contain the altered PA28.beta. gene.

L'invention concerne une souris transgénique présentant des modifications au niveau d'un gène PA28.beta., ladite souris étant obtenue par introduction d'un gène PA28.beta. modifié dans une souris hôte. Les animaux transgéniques ainsi obtenus ne produisent pas de molécules PA28 fonctionnelles. Les cellules et les lignées cellulaires dérivées de ces animaux renferment également le gène PA28.beta. modifié.

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