Pacap as a marker for cancer

Details Pacap as a marker for cancer Pacap as a marker for cancer

G - Physics

01

N

G01N 33/574 (2006.01)

Patent

CA 2742286

The present invention relates to a method aiding in the assessment of cancer. It discloses the use of the proapoptotic caspase adaptor protein (= PACAP) as a universal marker of different types of cancer. PACAP aids in the assessment of pulmonary or lung cancer (LC), particularly of non-small cell lung carcinoma (NSCLC), but also of other specific types of cancer. Such specific types of cancer are e.g. colon, bladder, cervix, ovary, endometrial, head and neck, breast, melanoma, pancreas, kidney, prostate, esophagus, stomach or bile duct cancer. Furthermore, the present invention especially relates to a method for assessing cancer from a liquid sample, derived from an individual by measuring PACAP in said sample. Measurement of PACAP can, e.g., be used in the early detection of cancer or in the surveillance of patients who undergo surgery.

La présente invention concerne un procédé contribuant à lévaluation du cancer. Elle a pour objet lutilisation de la protéine adaptatrice de cascade pro-apoptotique (= PACAP) en tant que marqueur universel de différents types de cancer. PACAP contribue à lévaluation du cancer pulmonaire ou cancer du poumon (LC), en particulier du carcinome du poumon à grandes cellules (NSCLC), mais également dautres types spécifiques de cancer. De tels types spécifiques de cancer sont, par exemple, le cancer du côlon, de la vessie, du col de lutérus, ovarien, endométrial, de la tête et du cou, du sein, mélanome, du pancréas, du rein, de la prostate, de lsophage, de lestomac ou des voies biliaires. De plus, la présente invention concerne en particulier un procédé pour évaluer un cancer à partir dun échantillon liquide, dérivé dun individu en mesurant PACAP dans ledit échantillon. La mesure de PACAP peut, par exemple, être utilisée dans la détection précoce du cancer ou la surveillance de patients qui subissent une chirurgie.

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