Packings for liquid chromatography, process for preparing...

Details Packings for liquid chromatography, process for preparing... Packings for liquid chromatography, process for preparing...

G - Physics

01

N

G01N 30/56 (2006.01) B01J 20/32 (2006.01) G01N 30/02 (2006.01)

Patent

CA 2458133

The present invention provides packings for high performance liquid chromatography whose residual silanol groups are extremely reduced and which remarkably prevent tailing of basic compounds. Endcapping agents represented by the following general formula [II] are reacted in liquid phases or gas phases with silica gel which is surface-modified with chemical modifying agents to link the endcapping agents to the residual silanol groups on the silica gel surface. In the formula, R3 and R4, the same or different, are alkyl having one to four carbon atoms, and n is the factor of structural unit and an integer of 2 to 10. (see formula II)

La présente invention a pour objet des phases stationnaires pour colonnes de chromatographie en phase liquide haute performance dont les groupes silanols résiduels sont extrêmement réduits, ce qui prévient remarquablement la traînée des pics des composés basiques. On fait réagir des agents d'end-capping, représentés par la formule générale suivante ¬II|, en phase liquide ou gazeuse avec du gel de silice dont la surface est modifiée au moyen d'agents chimiques afin de lier les agents d'end capping aux groupes silanols résiduels à la surface du gel de silice. Dans la formule, R3 et R4, identiques ou différents, sont des groupes alkyles comportant de un à quatre atomes de carbone, n est le facteur d'unité structurelle et un nombre entier de 2 à 10. Image

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