Parathyroid hormone analogues for the treatment of osteoporosis

Details Parathyroid hormone analogues for the treatment of osteoporosis Parathyroid hormone analogues for the treatment of osteoporosis

C - Chemistry, Metallurgy

07

K

C07K 14/635 (2006.01) C07K 7/54 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2126299

Certain analogues of human parathyroid hormone (hPTH) have been found to be effective for the treatment of osteoporosis, while showing decreased side effects. Analogues showing this effect include all sequences from hPTH-(1-28)-NH2 to hPTH- (1-31)-NH2 and all sequences from [Leu27]-hPTH-(1-28)-NH2 to [Leu27]-hPTH-(1-34)-NH2. Also included are cyclic analogues cyclo(Lys26-Asp30)[Leu27]-hPTH-(1-34)NH2 and cyclo (Lys27-Asp30)- hPTH-(1-34)-NH2. Analogues in the form of the carboxyl terminal amide are particularly effective.

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