A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/38 (2006.01) A61K 35/26 (2006.01) A61K 35/28 (2006.01) A61K 39/00 (2006.01) C07K 14/72 (2006.01) C12N 5/00 (2006.01) C12N 5/02 (2006.01)
Patent
CA 2492295
The invention relates to methods for manipulating hematopoietic progenitor cells and related products. In one aspect the invention relates to the use of agents that activate a PTH/PTHrP receptor to enhance the growth and maintenance of hematopoietic progenitor cells in vivo and in vitro, to enhance mobilization of hematopoietic stem cells, to improve the efficiency of targeting cells to the bone marrow, and/or to modulate hematopoietic progenitor cell function.
L'invention concerne des proc~d~s pour manipuler des cellules prog~nitrices h~matopo~~tiques et des produits associ~s. Un aspect de l'invention concerne l'utilisation d'agents activant un r~cepteur PTH/PTHrP pour promouvoir la croissance et la maintenance de cellules prog~nitrices h~matopo~~tiques in vivo et in vitro, pour promouvoir la mobilisation de cellules souches h~matopo~~tiques, pour am~liorer l'efficacit~ du ciblage de cellules dans la moelle osseuse et/ou pour moduler la fonction de cellules prog~nitrices h~matopo~~tiques.
Adams Gregor B.
Calvi Laura M.
Kronenberg Henry M.
Scadden David T.
Mbm Intellectual Property Law Llp
The General Hospital Corporation
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