Parenteral administration of 6-hydroxy-oxymorphone for use...

Details Parenteral administration of 6-hydroxy-oxymorphone for use... Parenteral administration of 6-hydroxy-oxymorphone for use...

A - Human Necessities

61

K

A61K 31/485 (2006.01) A61K 9/00 (2006.01) A61K 9/20 (2006.01) A61P 25/04 (2006.01)

Patent

CA 2452872

In a method of treating pain a patient is administered a pharmaceutical composition of 6-hydroxy oxymorphone in an amount sufficient to induce analgesia. In one embodiment,the pharmaceutical composition is administered parenterally, preferably by injection and intravenous drip. To achieve the desired analgesic effect, blood plasma levels of 6-hydroxy oxymorphone are raised to at least approximately 0.05 ng/mL during treatment. Administration of compositions containing 6-hidroxy oxymorphone, and one or more carriers, diluents, and excipients in an amount sufficient to induce analgesia is also contemplated.

Dans une méthode de traitement de la douleur, une composition pharmaceutique de 6-hydroxy oxymorphone est administrée à un patient en une dose suffisante pour induire une analgésie. Dans un mode de réalisation, la composition pharmaceutique est administrée par voie parentérale, de préférence par injection et par goutte-à-goutte intraveineux. Pour obtenir l'effet analgésique voulu, les niveaux de 6-hydroxy oxymorphone dans le plasma sanguin sont élevés jusqu'à au moins approximativement 0,05 ng/ML. Idéalement, les niveaux de 6-hydroxy oxymorphone dans le plasma sanguin s'établissent au moins à 0,075 ng/ML pendant le traitement. Est également prévue l'administration de compositions contenant la 6-hydroxy oxymorphone, ainsi qu'un ou plusieurs supports, diluants, et excipients en une dose suffisante pour induire une analgésie.

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