Partial and full agonists of a1 adenosine receptors

Details Partial and full agonists of a1 adenosine receptors Partial and full agonists of a1 adenosine receptors

C - Chemistry, Metallurgy

07

H

C07H 19/16 (2006.01)

Patent

CA 2476683

Disclosed are novel compounds that are partial and full A1 adenosine receptor agonists, useful for treating various disease states, in particular tachycardia and atrial flutter, angina, myocardial infarction and hyperlipidemia. In one aspect, the invention relates to a compound of formula I: (see formula I) or a pharmaceutically acceptable salt thereof, wherein: R1 is cyclopentyl or cyclohexyl, either of which may be optionally substituted with hydroxy or -CO2CH2CH3; R2 is hydrogen; R3 is phenyl, isoxazolyl, thiophenyl, or thiazolyl, any of which may be optionally substituted with one or more substituents selected from methyl, methoxy, fluoro, and chloro; R4 and R5 are hydrogen; T is a covalent bond or methylene; X is a covalent bond; Y is -O-, -S-, -NH-, or a covalent bond; and Z is methylene or ethylene.

L'invention porte sur de nouveaux compos~s qui sont des agonistes partiels et complets des r~cepteurs de l'ad~nosine A´1?, et qui sont utiles dans le traitement de divers ~tats pathologiques, notamment la tachycardie et le flutter auriculaire, l'angine, l'infarctus du myocarde et l'hyperlipid~mie.

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