C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
530/1, 530/5.06,
C07K 5/06 (2006.01) C07C 271/22 (2006.01) C07K 1/00 (2006.01) C07K 5/02 (2006.01)
Patent
CA 1318457
ABSTRACT OF THE DISCLOSURE: New partially retro-inverted tuftsin analogues of general formula Image wherein R represents the side-chain of the amino acids threonine, methionine or leucine, R1 represents the side- chain of the amino acids lysine or arginine, R2 is hydrogen or a metabolically labile acyl group. All the asymmetric carbon atoms are either of the S- or R-configuration, or, alternatively, the first, third, and fourth asymmetric carbons, starting from the N-terminal residue, are of the S- configuration while the second one is of the R- or (R,S)- configuration, and the corresponding pharmacologically acceptable salts, esters and amides. The new compounds share the pharmacological properties of tuftsin that is stimulating phagocytosis, antibacterial activity of the macrophages and has potential as an immunostimulating, antibacterial and antitumor drug, are more stable toward the enzymatic degradation than the parent molecule.
541628
Bonelli Fabio
Boraschi Diana
Cardinali Franco
Censini Stefano
Di Trapani Romano
Eniricerche S.p.a.
Robic
Sclavo S.p.a.
LandOfFree
Partially retro-inverted tuftsin analogues, method for the... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Partially retro-inverted tuftsin analogues, method for the..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Partially retro-inverted tuftsin analogues, method for the... will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1271229