Peg-conjugates of hgf-nk4

Details Peg-conjugates of hgf-nk4 Peg-conjugates of hgf-nk4

A - Human Necessities

61

K

A61K 47/48 (2006.01)

Patent

CA 2438308

A conjugate comprising an N-terminal fragment of hepatocyte growth factor (HGF/SF) consisting of the hairpin domain and the four kringle regions of the .alpha.-chain and a polyethylene glycol group having an overall molecular weight of from about 20 to 40 kDA, has improved properties is a useful therapeutic agent for tumor treatment.

L'invention concerne un conjugué comprenant un fragment terminal de facteur de croissance d'hépatocyte (HGF/SF) constitué du domaine en épingle à cheveux et des quatre régions kringle de la chaîne .alpha. ainsi qu'un groupe de polyéthylène glycole dont le poids moléculaire global est compris entre environ 20 et 40 kDA. L'invention faisant preuve de propriétés améliorées constitue un agent thérapeutique utile dans le traitement des tumeurs.

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