Peptide and peptide mimetic derivatives having integrin...

Details Peptide and peptide mimetic derivatives having integrin... Peptide and peptide mimetic derivatives having integrin...

C - Chemistry, Metallurgy

07

K

C07K 7/64 (2006.01) A61K 38/08 (2006.01) A61K 38/10 (2006.01) A61K 38/12 (2006.01) A61L 27/04 (2006.01) A61L 27/22 (2006.01) A61L 27/54 (2006.01) C07K 5/12 (2006.01) C07K 7/06 (2006.01) C07K 7/08 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2469528

Compounds of the formula I B-Q-X1, in which B is a bioactive, cell-adhesion-promoting molecule, Q is absent or is an organic spacer molecule, and X1 is an anchor molecule, selected from the group consisting of -W(i), -V-W(ii), -V-[V-W2]2 (iii) and -V-[V-(V-W2)2]2 (iv) where W is (see formula I) and V is Lys, Asp or Glu, m is 1, 2 or 3 and n is in each case, independently of one another, 0, 1, 2, 3, 4, 5, 6, 7 or 8; YY is an amino or carboxyl group. A free amino group of group B is linked in a peptide-like manner to a free carboxyl group of the spacer molecule Q or of the anchor molecule X1 or a free amino group of the radical Q is linked in a peptide-like manner to a free carboxyl group of the radical X1, and salts thereof, as integrin inhibitors for the treatment of diseases, defects and inflammation caused by implants and of osteolytic diseases, such as osteoporosis, thrombosis, cardiac infarction and arteriosclerosis, and for the acceleration and strengthening of the integration process of the implant or of the biocompatible surface into the tissue.

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