Peptide conjugates, use thereof as a drug, and compositions...

Details Peptide conjugates, use thereof as a drug, and compositions... Peptide conjugates, use thereof as a drug, and compositions...

C - Chemistry, Metallurgy

07

K

C07K 7/06 (2006.01) A61K 8/36 (2006.01) A61K 8/64 (2006.01) A61K 38/06 (2006.01) A61K 38/07 (2006.01) A61K 38/08 (2006.01) A61Q 19/00 (2006.01) C07K 5/08 (2006.01) C07K 5/093 (2006.01) C07K 5/10 (2006.01) C07K 5/11 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2237993

Peptide conjugates including a sequence of at least three amino acids selected from Lys-Lys-Gly, Gly-His-Lys and Glu-His-Lys, wherein "Lys" is Lysine or a halogenated derivative thereof, or a methylated Lysine derivative, particularly Methyl-Lysine and Dihydrobromo-Methyl-Lysine, said amino acids optionally being in D, L or DL form, and said sequence being chemically or physically conjugated with at least one compound selected from monocarboxylic acids of general formula (I): HOOC-R, or alcohol, aldehyde or amide derivatives thereof, and dicarboxylic acids of general formula (II): HOOC-R¿1?-COOH, are disclosed. The use of such conjugates as a drug, and pharmaceutical or cosmetic compositions containing said conjugates, are also disclosed.

L'invention concerne des conjugués peptidiques comprenant une séquence d'au moins 3 acides aminés choisis parmi Lys-Lys-Gly, Gly-His-Lys et Glu-His-Lys, dans laquelle "Lys" représente la Lysine ou un dérivé halogéné de la Lysine, ou un dérivé méthylé de la Lysine, notamment Méthyl-Lysine et Dihydrobromo- Méthyl-Lysine, les acides aminés pouvant être sous la forme D, L ou DL; ladite séquence étant conjuguée chimiquement ou physiquement avec au moins un composé sélectionné parmi les acides monocarboxyliques de formule générale (I): HOOC- R, ainsi que leurs dérivés alcool, aldéhyde ou amide; les acides dicarboxyliques de formule générale (II): HOOC-R1-COOH. Elle concerne également leur utilisation à titre de médicament et des compositions pharmaceutiques ou cosmétologiques les contenant.

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