Peptide inhibitors for mediating stress responses

A - Human Necessities – 61 – K

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A61K 38/10 (2006.01)

Patent

CA 2577196

The present invention relates to peptides capable of inhibiting cellular and immune stress responses in a eukaryotic cell. The invention provides compositions and methods for the treatment of human degenerative diseases and inflammation, utilizing peptides recognized by monoclonal anti-DNA antibodies, the peptides having anti-apoptotic and anti-inflammatory activity. The invention further provides antibody molecules and uses thereof for the isolation of such peptides.

La présente invention concerne des peptides capables d'inhiber des réponses cellulaires et immunes au stress dans une cellule eucaryote. Cette invention concerne également des compositions et des méthodes permettant de traiter des inflammations et des maladies dégénératives chez l'humain, au moyen de peptides reconnus par des anticorps monoclonaux anti-ADN; ces peptides présentant une activité anti-apoptotique et anti-inflammatoire. Cette invention concerne également des molécules d'anticorps ainsi que les différentes utilisations de celles-ci pour isoler de tels peptides.

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